Publications

  • Douja Chamseddine, Siraje A. Mahmud, Aundrea K. Westfall, Todd A. Castoe, Rance E. Berg, Mark W. Pellegrino, The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response, Cell Reports, Volume 41, Issue 11, 2022, 111789, ISSN 2211-1247
  • Perry BW, Gopalan SS, Pasquesi GIM, Schield DR, Westfall AK, Smith CF, Koludarov I, Chippindale PT, Pellegrino MW, Chuong EB, Mackessy SP, Castoe TA. Snake venom gene expression is coordinated by novel regulatory architecture and the integration of multiple co-opted vertebrate pathways. Genome Res. 2022 Jun;32(6):1058-1073. doi: 10.1101/gr.276251.121. Epub 2022 Jun 1. PMID: 35649579; PMCID: PMC9248877.
  • Westfall AK, Perry BW, Kamal AHM, Hales NR, Kay JC, Sapkota M, Schield DR, Pellegrino MW, Secor SM, Chowdhury SM, Castoe TA. Identification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration. BMC Genomics. 2022 Jan 4;23(1):6. doi: 10.1186/s12864-021-08226-5. PMID: 34983392; PMCID: PMC8725436.
  • SA Mahmud, MA Qureshi, MW Pellegrino; On the offense and defense: mitochondrial recovery programs amidst targeted pathogenic assault. The FEBS Journal 16 July 2021; febs.16126
  • Madhab Sapkota, Mohammed Adnan Qureshi, Siraje Arif Mahmud, Yves Balikosa, Charlton Nguyen, Joseph M. Boll, Mark W. Pellegrino; A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity. Biol Open 15 May 2021; 10 (5): bio058613.
  • Mustafi Raisa Amin, Siraje Arif Mahmud, Jonathan L Dowgielewicz, Madhab Sapkota, Mark W Pellegrino. 2020. A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR. PLoS Genetics. 2020; e1009234
  • SA Mahmud, MA Qureshi, M Sapkota, MW Pellegrino. 2020. A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR. PLoS pathogens. 2020; e1008918
  • Perry BW, Andrew AL, Mostafa Kamal AH, Card DC, Schield DR, Pasquesi GIM, Pellegrino MW, Mackessy SP, Chowdhury SM, Secor SM, Castoe TA. 2019. Multi-species comparisons of snakes identify coordinated signalling networks underlying post-feeding intestinal regeneration. Proc Biol Sci. 2019 Jul 10;286(1906):20190910. 
  • Dimos BA, Mahmud SA, Fuess LE, Mydlarz LD, Pellegrino MW. 2019. Uncovering a mitochondrial unfolded protein response in corals and its role in adapting to a changing world. Proc Biol Sci. 2019 Jun 26;286(1905):20190470.
  • Lee Y, Hamann JC, Pellegrino M, Durgan J, Domart MC, Collinson LM, Haynes CM, Florey O, Overholtzer M. 2019. Entosis Controls a Developmental Cell Clearance in C. elegans. Cell Rep. 2019 Mar 19;26(12):3212-3220.e4.
  • Qureshi, M.A, Haynes, C.M., and Pellegrino, M.W. 2017. The mitochondrial unfolded protein response: signaling from the powerhouse. J. Biol. Chem. 292: 13500-13506.
  • Fiorese, C.J., Schultz, A.M., Lin, Y.F., Rosin, N., Pellegrino, M.W., and Haynes C.M. 2016. The transcription factor ATF5 mediates a mammalian mitochondrial UPR. Current Biology. 26: 2037-43.
  • Lin, Y.F., Schultz, A.M, Pellegrino, M.W., Lu, Y., Shaham, S., Haynes, C.M. 2016. Maintenance and propagation of deleterious mitochondrial genomes by the mitochondrial UPR. Nature. 533: 416-9.
  • Pellegrino, M.W. and Haynes C.M. 2015. Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection. BMC Biology. 13: 22-7.
  • Nargund, A.M., Fiorese, C.J., Pellegrino M.W., Deng, P., and Haynes, C.M. 2015. Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS during the UPRmt. Mol Cell. 58:123-33.
  • Pellegrino, M.W., Nargund A.M., Kirienko, N., Gillis, R., Fiorese, C.F., and Haynes C.M. 2014. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 516:414-7.
  • Nargund A.M*., Pellegrino, M.W.*, Fiorese, C.J., Baker, B.M. and Haynes, C.M. 2012. Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation. Science. 337:587-590.
  • *shared co-first authorship
  • Pellegrino, M.W. and Haynes C.M. 2012. Signaling the Mitochondrial Unfolded Protein Response. 2012. Biochem. Biophys. Acta. 1833: 410-416.
  • Pellegrino, M.W. and Hajnal A. 2012. The Transcription Factor VAB-23 links Vulva Cell Specification and Morphogenesis. Worm. 1:170-175.
  • Farooqui S., Pellegrino M.W., Rimann I., Morf M.K., Müller L., Fröhli E., Hajnal A. 2012. Coordinated lumen contraction and expansion during vulval tube morphogenesis in Caenorhabditis elegans. Developmental Cell. 23: 494-506.
  • Pellegrino, M.W., Farooqui, S., Fröhli, E., Rehrauer H., Kaeser-Pebernard, S., Müller F., Gasser R.B., and Hajnal, A. 2011. LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein. Development. 138: 4649-4660.
  • Pellegrino M.W., Gasser R.B , Stetak A., Sprenger F. and Hajnal, A. 2009. The conserved zinc finger protein VAB-23 is an essential regulator of epidermal morphogenesis in C. elegans. Developmental Biology. 336: 84-93.
  • Pellegrino M., Furmaniak-Kazmierczak E., Leblanc J.C., Cho T., Cao K., Marcovina S.M., Boffa M.B., Cote G.P., Koschinsky M.L. 2004. The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells. J. Biol. Chem. 279: 6526-33.
  • Hu M., Zhong W., Cambpell B.E., Sternberg P., Pellegrino M.W and Gasser R.B. 2009 Elucidating ANTs in worms using genomic and bioinformatic tools – biotechnological prospects? Biotechnology Advances. 28: 49-60
  • Hu M., Campbell B.E., Pellegrino M., Loukas A., Beveridge I., Ranganathan S., Gasser R.B. 2007. Genomic characterization of Tv-ant-1, a Caenorhabditis elegans tag-61 homologue from the parasitic nematode Trichostrongylus vitrinus. Gene. 397: 12-25.
  • Nisbet A.J., Geldhof, Pellegrino M., Gasser R.B. 2006. Characterisation of a DM domain containing transcription factor from Trichostrongylus vitrinus (Nematoda: Strongylida). Parasitol Int. 55: 155-7.